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2.Bg5 against …h6, …g5, …Nh5
2.Bg5 d6 3.Nd2 Nbd7 4.Ngf3 h6: 5 games, 20%. And when Black follows up with …g5 and …Nh5, 0% over 4 games. The engine, though, gives you the edge all the way: it's not the position that makes you lose, it's the plan afterwards.
Review: 1.d4 Nf6 2.Nf3 c5. Your answer?