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Against …c5: push d5
After 1.d4 c5, you play 2.c3 in all 22 games in your file, for 48%. The engine prefers 2.d5: your file puts the cost at 6.7 points of winning chances. Same reflex after 1.d4 Nf6 2.Nf3 c5: 3.c3 in 10 games. It works there (70%), but it gives back the advantage that 3.d5 keeps.
Review: after 5.Ne5 c5, Black hasn't castled. Your move?